Patricia SimePatricia Sime, MD

Professor and chair


Internal medicine

Research group

Sime lab

Research areas

The Sime laboratory focuses on identifying pathogenetic mechanisms underlying lung disease so that we can speed the identification and development of new and exciting therapeutics. Diseases we study include lung scarring (fibrosis) and smoke and other toxicant induced lung inflammatory diseases such as chronic bronchitis and emphysema (COPD). Our team studies are translational in nature with our work bridging in vitro studies to in vivo models of human disease and patient studies. We have also been involved in both investigator-initiated and pharma sponsored clinical trials, and are fortunate to have been funded continuously by the NIH as well as Department of Defense, the American Lung Association, industry and philanthropy. An important mission of the lab is to help train the next generation of basic, translational and clinical researchers. We are fortunate to collaborate widely across the institution, nationally and internationally and have a team-based approach to problem solving. Our trainees have been supported by NIH training grants including NIH T32s, F and K awards and are enjoying successful careers in academia, industry and government. Our trainees include graduate students, clinical fellows and post-doctoral fellows. All are welcome!

See full bibliography


  • Sarah Spiegel
  • Rebecca Heise
  • Robert Winn
  • Patrick Nana-Sinkam
  • Antonio Abbate

CHRI theme

Personalized and Translational Medicine