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Frances Saccoccio, MD, PhD

Assistant Professor

Specialties

Infectious diseases

Call 804-828-CHOR (2467)

Locations

Children's Pavilion

1000 East Broad Street
Richmond, VA 23219

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Areas of interest

Antimicrobial stewardship
Congenital infections
Transplant infectious diseases

Bio

Dr. Saccoccio returned to CHoR after completing advanced fellowship training in infectious diseases at Duke University. During fellowship, Dr. Saccoccio was awarded a Thrasher early career award and Pediatric Infectious Diseases Society fellowship award for her research on congenital cytomegalovirus. She was also awarded several Children Miracle Network awards for a variety of projects.

She was previously a clinical assistant professor at UF Health Shands Children's Hospital in Gainesville, FL. Dr. Saccoccio serves as the director of antimicrobial stewardship at CHoR. She is a member of the American Academy of Pediatrics, Pediatric Infectious Diseases Society, and Infectious Diseases Society of America.

Dr. Saccoccio is excited to be back in Richmond. She enjoys exploring the local river trails with her husband, son and rescue puppy.

Education

Medical school VCU School of Medicine

Residency Children's Hospital of Richmond at VCU

Fellowship Duke University Medical Center

Research interests

Dr. Saccocio's research during medical training focused on congenital cytomegalovirus and vaccine development. She has continued this work and is also interested in infections in immune compromised hosts and antimicrobial stewardship.

Publications

Cornberg M, Sheridan BS, Saccoccio FM, Brehm MA, Selin LK. Protection against vaccinia virus challenge by CD8 memory T cells resolved by molecular mimicry. J Virol. 2007 Jan;81(2):934-44. PubMed PMID: 17079318; PubMed Central PMCID: PMC1797447.
Cornberg M, Clute SC, Watkin LB, Saccoccio FM, Kim SK, Naumov YN, Brehm MA, Aslan N, Welsh RM, Selin LK. CD8 T cell cross-reactivity networks mediate heterologous immunity in human EBV and murine vaccinia virus infections. JImmunol. 2010 Mar 15;184(6):2825-38. PubMed PMID: 20164414; PubMed Central PMCID: PMC3253758.
Saccoccio FM, Sauer AL, Cui X, Armstrong AE, Habib el-SE, Johnson DC, Ryckman BJ, Klingelhutz AJ, Adler SP, McVoy MA. Peptides from cytomegalovirus UL130 and UL131 proteins induce high titer antibodies that block viral entry into mucosal epithelial cells. Vaccine. 2011 Mar 24;29(15):2705-11. PubMed PMID: 21310190; PubMed Central PMCID: PMC3084484.
Saccoccio FM, Gallagher MK, Adler SP, McVoy MA. Neutralizing activity of saliva against cytomegalovirus. Clin Vaccine Immunol. 2011 Sep;18(9):1536-42. PubMed PMID: 21795465; PubMed Central PMCID: PMC3165217.
McVoy MA, Lee R, Saccoccio FM, Hartikka J, Smith LR, Mahajan R, Wang JB, Cui X, Adler SP. A cytomegalovirus DNA vaccine induces antibodies that block viral entry into fibroblasts and epithelial cells. Vaccine. 2015 Dec 16;33(51):7328-36. PubMed PMID: 26597035; PubMed Central PMCID: PMC4684450.
Burghuber CK, Manook M, Ezekian B, Gibby AC, Leopardi FV, Song M, Jenks J, Saccoccio F, Permar S, Farris AB, Iwakoshi NN, Kwun J, Knechtle SJ. Dual targeting: combining costimulation blockade and bortezomib to permit kidney transplantation in sensitized recipients. Am J Transplant. 2019; Mar;19(3):724-736. PubMed PMID: 30102844.
Saccoccio FM, Jenks JA, Itell HL, Li SK, Berry M, Pollara J, Casper C, Gantt S, Permar SR. Humoral immune correlates for protection of postnatal cytomegalovirus acquisition. J Infect Dis. 2019 Jul 31;220(5):772-780. PubMed PMID: 31107951; PubMed Central PMCID: PMC6667799.
Ezekian B, Schroeder PM, Mulvihill MS, Barbas A, Collins B, Freischlag K, Yoon J, Yi JS, Smith F, Olaso D, Saccoccio FM, Permar S, Farris AB, Kwun J, Knechtle SJ. Pretransplant desensitization with costimulation blockade and proteasome inhibitor reduces DSA and delays antibody-mediated rejection in highly sensitized nonhuman primary kidney transplant reciepients. J am Soc Nephrol. 2019 Dec; 30(12):2399-2411. PubMed PMID: 31658991.
DeNoble, AE, Saccoccio FM, Permar, SR, Hughes BL. Prenatal treatment of congenital cytomegalovirus with valganciclovir: A case report. Clin Infect Dis 2020 Dec 3;71(9):2506-25-8. PMID: 32198512. DOI: 10.1092/cid/ciaa305.
Anjum SK, Mangrola K, Fitzpartrick G, Stockdale K, Matthias L, Ali IKM, Cope JR, O’Laughlin K, Collins S, Beal SG, Saccoccio FM. A case report of primary amebic meningoencephalitis in North Florida. IDCases. 2021 Jun28;25:e01208. PubMed PMID 34307045.
Bryant T, Ellenwood S, Butters O, Saccoccio FM. An uncommon cause of soft tissue and knee infection after penetrating injury in a non-immunocompromised adolscent male. SAGE Open Med Case Rep. 2021 Aug 18:9:2050313X211064683. PubMed PMID 34434559.
Heston SM, Young RR, Tanaka JS, Jenkins K, Vinesett R, Saccoccio FM, Martin PL, Chao NJ, Kelly MS. Risk factors for CMV viremia and treatment-associated adverse events among pediatric hematopoietic stem cell transplant recipients. OFID 2021 Dec 16;9(2):ofab639. PMID 35111869
Rouse DJ, Fette LM, Hughes BL, Saade GR, Dinsmoor MJ, Reedy UM, Pass R, Allard D, Mallett G, Clifton RG, Saccoccio FM, Permar SR, Gyamfi-Bannerman C, Varner MW, Goodnight WH, Tita ATN, Costantine MM, Swamy GK, Heyborne KD, Chien EK, Chauhan SP, El-Sayed YY, Casey BM, parry S, Simhan HN, Napolitano PG, Macones GA, NICHD MFMU network. Noninvasive prediciton of congenital cytomegalovirus infection after maternal primary infection. Obst Gynecol 2022 Mar 1;139(3):400-406. PMID 35115450.
Lin S and Saccoccio FM. Cat scratch disease: Pediatric case series for varying presentations of Bartonella henselae. ID Cases 2023 Aug9:33:e01875. PMID 37609448
Mostrom MJ, Yu S, Tran D, Saccoccio FM, Versoza CJ, Malouli D, Mirza A, Valencia S, Gilbert M, Blair RV, Hansen S, Barry P, Fruh K, Jensen JF, Pfeifer SP, Kowalik TF, Permar SR, Kaur A. Protective effect of pre-existing natural immunity in a nonhuman primate reinfection model of congenital cytomegalovirus infection. PLOS Pathog. 2023 Oct 5;19(10):e1011646. PMID 37796819.

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