Judith Voynow, MD

Dr. Voynow is a member of the American Academy of Pediatrics, American Pediatric Society and American Thoracic Society.

Major grant funding for research includes:

• Cystic Fibrosis Foundation Research Grant: Neutrophil Elastase and Macrophage Extracellular Traps in CF
• Department of Defense Peer-Reviewed Medical Research Program: Neutrophil Elastase Reprograms Macrophage Function in Chronic Obstructive Pulmonary Disease
• NIH R01: The Trojan Horse Hypothesis: Neutrophil Elastase Reprograms Macrophage Function
• NIH R01

2018-2020:

• Apparao B. Kummarapurugu, Shuo Zheng, Abigail Pulsipher, Justin R. Savage, Jonathan Ma, Bruce K. Rubin, Thomas P. Kennedy, Judith A. Voynow, Polysulfated Hyaluronan GM-1111 inhibits elastase and improves rheology in CF sputum. 2020. Am. J. Respir. Cell Mol. Biol., in press.
• Gaston B, Laguna TA, Noah TL, Hagood J, Voynow J, Ferkol T, Hershenson M, Boyne K, Delecaris A, Ross K, Gozal D, Celedón JC, Abman SH, Moore P, Davis S, Cornfield DN, Murphy T. A proposal for the addressing the needs of the pediatric pulmonary work force. Pediatr Pulmonol. 2020 Aug;55(8):1859-1867. doi: 10.1002/ppul.24856. Epub 2020 Jun 12. PMID: 32531116
• Voynow JA, Zheng S, Kummarapurugu AB. Glycosaminoglycans as Multifunctional Anti-Elastase and Anti-Inflammatory Drugs in Cystic Fibrosis Lung Disease. Front Pharmacol. 2020 Jul 8;11:1011. doi: 10.3389/fphar.2020.01011. eCollection 2020. PMID: 32733248
• Voynow, JA, Fisher, K, Sunday, ME, Cotten, CM, Hamvas, A, Hendricks-Munoz, KD, Poindexter, BP, Pryhuber, GS, Ren, CL, Ryan, RM, Sharp, JE, Young,SP, Zhang, H, Greenberg, RG, Herring, AH, Davis, SD, Urine Gastrin Releasing Peptide in the First Week Correlates with BPD and Post-Prematurity Respiratory Disease. 2020. Pediatr Pulmonol. Apr;55(4):899-908. doi: 10.1002/ppul.24665. Epub 2020 Jan 29. PMID: 31995668
• Ryan RM, Keller RL, Poindexter BB, D'Angio CT, Shaw PA, Bellamy SL, Moore PE, McPherson C, Greenberg JM; PROP Investigators (Voynow JA, Co-investigator) Respiratory Medications in Infants <29 Weeks during the First Year Postdischarge: The Prematurity and Respiratory Outcomes Program (PROP) Consortium. J Pediatr. 2019 May;208:148-155.e3. doi: 10.1016/j.jpeds.2018.12.009. PMID: 30857774
• Ryan RM, Feng R, Bazacliu C, Ferkol TW, Ren CL, Mariani TJ, Poindexter BB, Wang F, Moore PE; Prematurity and Respiratory Outcome Program (PROP) Investigators (Voynow JA, Co-investigator). Black Race Is Associated with a Lower Risk of Bronchopulmonary Dysplasia. J Pediatr. 2019 Apr;207:130-135.e2. doi: 10.1016/j.jpeds.2018.11.025. PMID: 30612812
• Morla, S, Sankaranarayanan, NV, Afosah, DK, Kumar, M, Kummarapurugu, AB, Voynow, JA, Desai, UR, On the Process of Discovering Leads that Target the Heparin-Binding Site of Neutrophil Elastase in the Sputum of Cystic Fibrosis Patients. J. Med. Chem. 2019. 62(11):5501-5511. DOI: 10.1021/acs.jmedchem.9b00379. PMID: 31074986.
• Clement L. Ren, Rui Feng, Stephanie D. Davis, Eric Eichenwald, Alan Jobe, Paul E. Moore, Howard B. Panitch, Jack K. Sharp, Jeff Kisling, Charles Clem, and James S. Kemp; on behalf of the Prematurity and Respiratory Outcomes Program (Voynow JA, Co-investigator) Tidal Breathing Measurements at Discharge and Clinical Outcomes in Extremely Low Gestational Age Neonates. Ann Am Thorac Soc. 2018; 15 (11):1311–1319. DOI: 10.1513.
• Hamvas A, Feng R, Bi Y, Wang F, Bhattacharya S, Mereness J, Kaushal M, Cotten CM, Ballard PL, Mariani TJ; PROP Investigators. (Voynow JA, Co-investigator) Exome sequencing identifies gene variants and networks associated with extreme respiratory outcomes following preterm birth. BMC Genet. 2018;19(1):94. doi: 10.1186/s12863-018-0679-7.
• Kummarapurugu, A.B., Afosah, D.K., Sankaranarayanan, N.V., Gangji, R.N., Zheng, S., Kennedy, T., Rubin, B.K., Voynow, J.A., Desai, U.R. Molecular principles of heparin oligosaccharide-based inhibition of neutrophil elastase in cystic fibrosis. J. Biol. Chem. 2018.293(32):12480-12490. doi: 10.1074/jbc.RA118.002644. Epub 2018 Jun 14. PMID: 29903912
• Hendricks-Munoz, K., Xu, J., Voynow, J. Tracheal Aspirate VEGF and Sphingolipid metabolites in the preterm infant with later development of bronchopulmonary dysplasia. Pediatr. Pulmonol. 2018.53: 1046-1052. doi: 10.1002/ppul.24022. PMID: 29687638
• Jonathan T. Ma, Christina Tang, Le Kang, Judith A. Voynow, Bruce K. Rubin. Cystic Fibrosis Sputum Rheology Correlates With Both Acute and Longitudinal Changes in Lung Function. Chest. 2018. Aug;154(2):370-377. DOI: https://doi.org/10.1016/j.chest.2018.03.005. PMID: 29559310
• Blaisdell CJ, Troendle J, Zajicek A; Prematurity and Respiratory Outcomes Program (Voynow JA, Co-investigator). Acute Responses to Diuretic Therapy in Extremely Low Gestational Age Newborns: Results from the Prematurity and Respiratory Outcomes Program Cohort Study. J Pediatr. 2018 197:42-47.e1. doi: 10.1016/j.jpeds.2018.01.066. PMID: 29599068
• Ma, J., Rubin, B.K., Voynow, J.A. Mucins, Mucus and Goblet Cells. Chest. 2018 Jul;154(1):169-176. doi: 10.1016/j.chest.2017.11.008. PMID: 29170036
• Karandashova S, Kummarapurugu A, Zheng S, Kang L, Sun S, Rubin BK, Voynow JA. Neutrophil elastase correlates with increased sphingolipid content in cystic fibrosis sputum. Pediatr Pulmonol. 2018 Jul;53(7):872-880. doi: 10.1002/ppul.24001. Epub 2018 Apr 6. PMID: 29624923
• Karandashova, S., Kummarapurugu, A.B., Zheng, S., Chalfant, C., Voynow, J.A. Neutrophil elastase increases airway ceramide levels via upregulation of serine palmitoyltransferase. Am. J. Physiol. Lung Cell Mol. Physiol. 2018. 314: L206-L214. DOI: 10.1152/ajplung.00322.2017. PMID: 29025713
• Kummarapurugu, AB; Zheng, S; Ledford, J; Karandashova, S; Voynow, J. High Mobility Group Box 1 Upregulates MUC5AC and MUC5B Expression in Primary Airway Epithelial Cells. Am. J. Respir. Cell Mol. Biol. 2018. 58: 126-128. PMID: 29286856

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