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Zhihong Wang, MD, PhD

Zhihong Wang, MD, PhD

Associate professor

Specialty
Hematology and Oncology

Locations
Children's Pavilion
Main Hospital, 7th Floor

Appointments: (804) 828-CHOR (2467)

Board Certifications

Pediatrics
Pediatric hematology and oncology

Medical School

Beijing University, Beijing, China

Residency

Children's Hospital of Michigan, Detroit, MI

Fellowship

Children's Hospital of Michigan, Detroit, MI

Education

Post-Doc, Stanford University

Areas of Interest

Pediatric brain tumors
Childhood cancers
Neurofibromatosis
Pediatric blood diseases

Research Interests

Novel targeted therapy in brain tumors
Novel targeted therapy in pediatric cancers
Clinical trials
Cancer drug resistance

Research Projects

Deconstruction and Reconstitution of NF1 Cutaneous Neurofibromas (Co-I, PI R Mattingly), The Neurofibromatosis Therapeutic Acceleration Program (NTAP)

Targeted therapy in diffuse intrinsic pontine glioma (Co-PI, PI: Ge Y), Children's Hospital of Michigan Foundation

Development of a Novel Therapy for Children with high risk Neuroblastoma (Co-PI, PI: Ge, Y), Children's Hospital of Michigan Foundation

Novel therapy development in diffuse intrinsic pontine glioma (Co-PI, PI: Taub, J), Children's Hospital of Michigan Foundation

Monitoring Treatment Response with FLT-PET in Children with Neuroblastoma (Principal Investigator, Co-PI Anthony Shields), Herrick Foundation

Recent Publications

Knight T, Shatara M, Carvalho L, Altinok D, Poulik J, Wang ZJ. Dramatic Response to Trametinib in a Male Child with Neurofibromatosis Type 1 and Refractory Astrocytoma. Pediatric Blood & Cancer, 2018, accepted

Gupta N, Goumnerova L, Wang, Z, Kierran M, Prospective Assessment of Feasibility and Safety of Surgical Biopsy of Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma, Neuro-Oncology, 2018 May 5, PMID# 29741745

Hutchins K, Savasan S, Chu R, Thomas R, Strathdee L, Wang Z & Taub J, Clinical trial enrollment is associated with improved follow-up visit rates among survivors of childhood cancer, J. Pediatric Hematology/Oncology, 2018 April 17 PMID# 29668542

Wang Z, Ge Y, Altinok D, Poulik J, Sood S, Taub J, Edwards H, Kieran M & Miller, Concomitant use of panobinostat and re-irradiation in progressive DIPG: Report of 2 cases, J. Pediatric Hematology/Oncology, 2017 Aug;39(6):e332-e335. PMID: 28234741

Niu X, Zhao J, Ma J, Xie C, Edwards H, Wang G, Caldwell JT, Xiang S, Zhang X, Chu R, Wang ZJ, Lin H, Taub JW, Ge Y Binding of Released Bim to Mcl-1 is a Mechanism of Intrinsic Resistance to ABT-199 which can be Overcome by Combination with Daunorubicin or Cytarabine in AML Cells. Clin Cancer Res. 2016 Sep 1;22(17):4440-51 PMID: 27103402

Hanmod S*, Wang G, Edwards H, Buck S, Ge Y, Taub J and Wang Z, Targeting histone deacetylases (HDACs) and Wee1 for treating high-risk neuroblastoma, Pediatric Blood Cancer. 2015 Jan;62(1):52-9

Wang Z, Rao L, Bhambhani K, Miller K, Poulik J, Altinok D and Sood S. Diffuse Intrinsic Pontine Glioma Biopsy: A Single Institution Experience, Pediatric Blood Cancer. 2015 Jan;62(1):163-5.
An editorial commentary was written by Dr. Kieran M "Time to rethink the unthinkable: upfront biopsy of children with newly diagnosed diffuse intrinsic pontine glioma (DIPG)?, Pediatr Blood Cancer. 2015 Jan;62(1):3-4, regarding this publication.

Wang Z, Konski A, Sood S, Altinok D, and Poulik J, Inadvertent high dose therapy with temozolomide in a child with recurrent brain stem glioma followed by a clinical response, J. Pediatric Hematology/Oncology, 2014 Nov;36(8):e549-52

Wang G*, Edwards H, Caldwell JT, Buck SA, Qing WY, Taub JW, Ge Y, Wang Z, Panobinostat Synergistically Enhances the Cytotoxic Effects of Cisplatin, Doxorubicin or Etoposide on High-Risk Neuroblastoma Cells. PLoS One. 2013 Sep 30;8(9):e76662

Wang Z, Zhou J, Kanakapalli D, Buck S, Wu GS & Ravindranath Y, High level of mitogen-activated protein kinase phosphatase-1 expression is associated with cisplatin resistance in osteosarcoma, Pediatric Blood & Cancer. 2008 51(6):754

Bio

Dr. Wang is a member of the International Society of Pediatric Oncology, Society for Neuro-oncology, American Society of Pediatric Hematology/Oncology and American Society of Clinical Oncology. She has also been the recipient of the Wayne State University School of Medicine College Teaching Award.


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